The crash happened near Exit 190 near the Dickson City exit just before 5:30 Tuesday.
Troopers say Margo Bolanos, 58, a rear passenger died in the wreck.
The male driver of the vehicle, Vilko Raitmaier, 61 of Canada and an additional female passenger, Nina Bolanos, 55 of California were taken to a nearby hospital.
Traffic was backed up for at least an hour on Interstate 81.
The cause of this Lackawanna County crash is still under investigation.
Will have more details as it becomes available.
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